Design and construction of a synthetic E. coli protease inhibitor detecting biomachine Currently, protease inhibitors have effectively been used to treat various types of symptoms or diseases such as cardiovascular disease, diabetes, hypertension, and infectious diseases like Hepatitis C and HIV infections. Our research group has designed and developed E. coli’s natural secretory system as a system for selection of antibody fragments that can be used to inhibit protease function. HIV-1 protease is used as a model as an alternative treatment for HIV patients.
Fig. 1 Schematic representation of the synthetic E. coli protease inhibitor detecting biomachine.
Fig. 2 Application of the engineered platform, termed Functional Ligand-binding Identification by Tat-based Recognition of Associating Proteins (FLI-TRAP), to HIV-1 protease
Asst. Prof. Dr. Dujduan Waraho